Blistering diseases: Clinical features, pathogenesis, treatment

Atherosclerosis: Pathogenesis, Clinical Features and Treatment

Worldwide, more people die of the complications of a disease that has been a companion ofmankind since antiquity than of any other cause. This disease is called atherosclerosis. Macroscopic and microscopic evidence of atherosclerosis has been found in the aortas and the carotid, coronary and femoral arteries of mummies from Egypt, North America and China dating from around 3000 BC to AD 400 (Cu...

Rheumatoid Arthritis: Pathogenesis, Clinical Features, and Treatment

Clinical Features, Pathogenesis, and Treatment of Large Granular Lymphocyte Leukemias

Large granular lymphocytes (LGLs) are large lymphocytes with azurophilic granules in their cytoplasm. LGLs are either natural killer (NK) cells or T lymphocytes. Expansions of the LGLs in the peripheral blood are seen in various conditions, including three clonal disorders: T-cell LGL (T-LGL) leukemia, chronic lymphoproliferative disorders of NK cells (CLPD-NK), and aggressive NK-cell leukemia ...

Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome.

Guillain-Barré syndrome (GBS) is an important cause of acute neuromuscular paralysis. Molecular mimicry and a cross-reactive immune response play a crucial part in its pathogenesis, at least in those cases with a preceding Campylobacter jejuni infection and with antibodies to gangliosides. The type of preceding infection and patient-related host factors seem to determine the form and severity o...

Antiplectin autoantibodies in subepidermal blistering diseases.

BACKGROUND Hemidesmosomal proteins may become targets of autoimmunity in subepidermal blistering diseases. Well-known recognized autoantigens are the intracellular plaque protein BP230, the transmembrane BP180 and its shed ectodomain LAD-1. OBJECTIVES To establish the prevalence of autoimmunity against plectin, another intracellular plaque protein, and to investigate its antigenic sites. ME...